Modeling Risk Factors for Sleep- and Adiposity-Related Cardiometabolic Disease: Protocol for the Short Sleep Undermines Cardiometabolic Health (SLUMBRx) Observational Study

Background Obesity and short sleep duration are significant public health issues. Current evidence suggests that these conditions associated with cardiovascular disease, metabolic syndrome, inflammation, premature mortality. Increased interest in the potential link between obesity duration, its consequences, has been driven by apparent parallel increase prevalence of both recent decades, their overlapping association cardiometabolic outcomes, causal connection two The SLUMBRx (Short Sleep Undermines Cardiometabolic Health) study seeks to contribute development a comprehensive adiposity-sleep model while laying groundwork for future research program will be designed prevent treat adiposity- sleep-related disease risk factors. Objective This aims address 4 topics pertinent hypothesis: relationship adiposity duration; sex-based differences influence indices on outcomes; role socioecological factors as effect modifiers indices, sleep, outcomes. Methods employ large-scale survey (n=1000), recruiting 159 participants (53 normal weight, 53 overweight, obese) assessed 2 phases. Results was funded National Institutes Health, Heart, Lung, Blood Institute through K01 grant award mechanism (1K01HL145128-01A1) July 23, 2019. Institutional Review Board (IRB) approval project sought obtained 10, Phase 1 SLUMBRx, laboratory-based component study, gather objective (air displacement plethysmography anthropometrics) data (blood pressure, pulse wave velocity analysis, blood-based biomarker). 1-week, home-based (home testing or apnea, actigraphy, diaries). During phase 2, detailed demographic collected contextualize hypothesized sleep-associated Collection analyses yield information necessary customize observational intervention research. Conclusions Precise implementation protocol promises provide empirical interaction body composition duration. hypotheses tested important understanding pathogenesis developing interventions conception consequences. International Registered Report Identifier (IRRID) PRR1-10.2196/27139